Research Project: Chemical substances and female fertility

Project leader
Pauliina Damdimopoulou, Institutionen för klinisk vetenskap, intervention och teknik - CLINTEC Karolinska institutet
Project Members
Lars Berglund
Project Period
-
Project Status
Present
Description
This project is part of the international project FREIA (http://freiaproject.eu/wp/), which is funded by the EU. The project's purpose is to identify chemicals associated with the outcomes of in vitro fertilization and to investigate whether there is a relationship between lifestyle factors and chemicals.
We have examined 185 women who underwent egg retrieval for in vitro fertilization in Sweden. They have answered questions about lifestyle factors, such as home environment, personal care product usage, and dietary habits in a questionnaire. We are investigating the relationship of these factors to a number of chemicals.
Associations were found between frequent use of perfume, consumption of chicken eggs, and consumption of white fish and concentrations of endocrine-disrupting chemicals in ovarian follicular fluid (Hallberg et al. 2023). These results can be used to develop lifestyle recommendations to mitigate potential adverse health outcomes and fertility issues associated with chemical exposure and to inform decision-making on chemical matters. See information from the journal: https://www.linkedin.com/feed/update/urn:li:activity:7089597170340782080/
In a previous study, we examined 30 chemicals in blood and follicular fluid of these women and investigated the associations between the chemicals and the likelihood of having a live-born child. The results showed, among other things, that hexachlorobenzene, an organochlorine pesticide, was associated with the likelihood of having a live-born child (Björvang et al. 2022).
The project is a collaboration between Högskolan Dalarna, Uppsala University, the Karolinska Institute, and the Carl von Linné Clinic.
Keywords
Kemikalier, IVF-utfall, livsstilsfaktorer, Chemicals, IVF outcome, lifestyle factors
Research Profile
Health and Social Welfare
Subject
Medical Science
Financiers
EU Horizon 2020
Publications